NEUROPATHOLOGY
NEWSLETTER
American Association of Neuropathologists
Volume 9, Number 3     October, 1998


IN THIS ISSUE
1998 Annual Meeting and Awards
    Business Meeting
    Diagnoistic Slide Session
    Awards
Future Meetings
1999 Meeting
    Abstracts and Copyright Release/Conflict of Interest Forms
    Special Course
    Presidential Symposium
    Matthew T. Moore Lecture
    Saul R. Korey Lecture
    Business Meeting
    Diagnostic Slide Session
    Hotel Reservations and Meeting Registration
Professional Affairs Report
Membership
Newsletter and Society Information


1998 ANNUAL MEETING
Business Meeting — Minutes enclosed.

Diagnostic Slide Session — A copy of the case summaries is enclosed.

Awards
The Moore Award for the best paper related to clinical-pathological correlation was shared by two papers: Venkat R. Challa, D.M. Moody, W.R. Brown, D.M. Reboussin, M.A. Lovell and W. R. Markesbery whose paper was entitled "Recent developments in the pathology of brain injury during human and experimental cardio-pulmonary bypass", and Marla Gearing, J.R. Murrell, M.G. Spillantini, M. Goedert, R.A. Crowther, A.I. Levey, R. Jones, W. Walton, J.M. Shoffner, B.H. Wainer, M.L. Schmidt, J.Q. Trojanowski, B. Ghetti and S.S. Mirra whose paper was entitled "Tau cytopathology in a patient with familial early onset dementia and a mutation in the tau gene". Honorable mention for the Moore Award was given to O. Berezovska, M. Xia, R. Knowles and B.T. Hyman for their presentation "Expression of notch protein in adult brain parallels the expression of presenilin 1 and is elevated in Alzheimer disease".

The Weil Award for best paper in experimental neuropathology was given to E.J. Huang and L.F. Reichardt for their presentation entitled "Neurotropin-3 modulates expression of the POU domain factor BRN-3A in early sensory gangliogenesis". Honorable mention for the Weil Award was given to Kevin A. Roth and K.S. Shindler for their paper entitled "Caspase regulation of telencephalic survival".

The winner of the Rubinstein Award for best paper in neuro-oncology was BetteKay Kleinschmidt-DeMasters, L.C. Evans, M.A. Bitter, and K.R. Shroyer for their presentation entitled "Telomerase expression in cerebrospinal fluid as an adjunct to cytologic diagnosis". Honorable mention for the Rubinstein Award was given to H.G. Brown, P.T. Goldthwaite, J. L. Kepner and P.C. Burger for their presentation "Poor prognostic significance of "large cell" and "anaplastic" medulloblastomas — a Pediatric Oncology Group study".



Future Meetings
2000:Radisson Hotel, Atlanta, GA
June 8–11
2001:Holiday Inn—Mart Plaza, Chicago, IL
June 21–24



1999 ANNUAL MEETING
The next annual meeting will take place on June 17-20, 1999 at the Portland Hilton Hotel, Portland, Oregon. The abstracts will be published in the May, 1999 issue of The Journal of Neuropathology and Experimental Neurology.

Abstracts and Copyright Release/Conflict of Interest Forms (enclosed)

Abstracts for the Portland Meeting must be received by Friday, January 15, 1999. The abstract form, copies of the abstract, Copyright Release and Conflict of Interest forms (signed by the first author), Abstract Data Sheet, and completed (stamped) postcards should be sent to:

Bradley T. Hyman, MD, PhD
Chair, AANP Program Committee
Massachusetts General Hospital


Members who are sponsoring the abstract form of a non-member are asked to make certain that the authors have a copy of the instructions for abstract preparation and that the abstract form is properly prepared before signing it. As indicated in the instructions, the abstract must be signed by the Association member sponsoring the submission. Additional abstract forms may be obtained from the Secretary-Treasurer's office upon request. Please note that the abstract must be received by Friday, January 15, 1999. The Executive Council has instructed the Program Chair to refuse acceptance of any abstracts after that date.

Special Course (Thursday, June 17, 1999)

This year's course, "Infectious Diseases of the Nervous System" has been organized by our President, Jeannette J. Townsend.

Special Course Objectives

Infectious diseases of the nervous system play a significant role in neuropathology and new methodologies have increased the ease of diagnosis and array of treatment options. This course will cover a variety of infectious diseases in order to bring to the participants an update on both the clinical and research aspects of the organisms and how they interact with the nervous system. In the last decade an increasing number of immunosuppressed patients have appeared who are vulnerable to opportunistic infections. An update on the various organisms encountered in the immunosuppressed patient will be of help to those in clinical practice. A great deal of data has been gathered on the pathophysiology of cerebral malaria and will give us new insights into the ways this worldwide parasite causes disease in humans. Viral diseases offer a significant threat to the central nervous system. Rabies and HTLV-I represent two quite different viral diseases and these differences will lead to further insight concerning viral pathogenesis. Bacterial diseases of the central nervous system are common and treatable. Several unusual bacterial infections of the nervous system will be discussed in order to update the participants on pathogenesis, diagnosis and treatment. Neurosyphilis has resurfaced as a disease entity in the era of AIDS and this discussion will cover the pathology and offer an update on the disease as it presents today. Upon completion of the course, participants should have a greater understanding of infectious processes that involve the nervous system and be able to transfer this understanding to diagnostic applications.

TOPICS SPEAKERS
Opportunistic Infections Leroy R. Sharer (New Jersey Medical School)
Pathophysiology of Cerebral Malaria Gareth D. H. Turner (Oxford University)
Rabies Encephalitis in Humans Robert E. Mrak (University of Arkansas)
Immunopathogenesis of HTLV-I and and Associated Diseases Steve Jacobson (National Inst. of Health)
Lyme Disease and the CNS Patricia K. Coyle (SUNY, Stony Brook)
Campylobacter jejuni in the Guillain-Barre Syndrome Arthur K. Asbury (Univ. of Pennsylvania)
Neurosyphilis in the Era of AIDS Roger P. Simon (Univ. of Pittsburgh)
The American Association of Neuropathologists is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.

The American Association of Neuropathologists designates the above continuing medical education activity for 6 credit hours in Category I of the Physician's Recognition Award of the American Medical Association.

Presidential Symposium

President Jeannette J. Townsend is organizing the symposium entitled "Pathogenesis of CNS Infections" which will be held on Sunday morning, June 20, 1999. Dr. Townsend's Presidential Address will be entitled "Herpes Simplex Virus". Dr. Diane Griffin will speak on "Sindbis Virus", and Dr. Clayton A. Wiley will discuss "Human Immunodeficiency Virus".

Matthew T. Moore Lecture

As part of the Presidential Symposium, the Matthew T. Moore Distinguished Lecture is entitled "Viral Pathogenesis, an Overview" and will be presented by Dr. Richard T. Johnson of Johns Hopkins University.

Saul R. Korey Lecture

The lecture named in honor of Dr. Saul R. Korey will be given by Dr. William F. Hickey. This lecture will be held on Saturday, June 19th.

Business Meeting

The annual business meeting, to be held on Friday, June 18, and Saturday, June 19, will begin promptly at noon on both days.

Diagnostic Slide Session (Saturday, 8 PM, June 19)

Suitable cases for the Diagnostic Slide Session are being sought. If you have a case which you would like to present, send the slides and a clinical summary to:

E. Tessa Hedley-Whyte, M.D.
Neuropathology
Mass. General Hospital

If your case is selected, it will be necessary to provide 150 slides for distribution. Cases will be selected before February 1, 1999.

Protocols for the Diagnostic Slide Session will be available without charge at the registration desk. For additional information, please contact Dr. Leroy Sharer.

Hotel Reservations and Meeting Registration

Hotel reservation cards and registration information will be mailed with the March Newsletter.



Professional Affairs Report
Currently Graduate Medical Education (GME) is positioned at an important financial crossroad. The formula for who pays for GME has evolved substantially over the past decades. Since its inception, Medicare has shouldered a disproportionate share of GME funding. As Medicare's limitations become more evident, careful attention is being directed toward its scope of services and its compensation for training. Who will pay for GME in the future? It is clear that past reimbursement formulas will be revised. With increasing demand for primary care, it is not surprising that dollars for delivery or training of sub-specialists have shrunk. Will Medicare cease paying for specialty training? If so who will fill the gap? Sub-specialty training like Neuropathology has begun to experience these pressures and uncertainties. With a specialty as small as our own, I do not believe it is an overstatement to say that our very existence may be drawn into question. Without funded training positions will there be future Neuropathologists?

At the 1998 Annual AANP meeting the Professional Affairs Committee met and discussed creating a two-part survey designed to gather information on Neuropathology Fellowship programs. The first part of the survey will poll all currently listed NP Fellowship Directors to identify fellows trained in the last 5 years. The second part of the survey will poll all of the identified fellows regarding the success of their training programs. I would like to encourage all of the AANP members to help carry out this important survey. For these data to be of any use, the survey will need to be completed thoroughly and promptly. If the Directors will rapidly turn around the first portion of the survey, the committee can focus its efforts on gathering data from the more distributed past trainees

Clayton A. Wiley, M.D., Ph.D.
Vice President for Professional Affairs



Membership Information
Address Change Notification

Please send your address and phone number changes directly to the Secretary-Treasurer's Office. Notification to the Journal alone will not update the Association records. Also, please send us your FAX numbers and your EMAIL address, if available, for the 1999 Membership Directory. Changes or additions can be communicated on the 1999 dues notice form.

Membership Directory

The 1998 directory was mailed to all members in good standing in August. The Association is planning to post the membership directory on the AANP home page. If you wish to have your name included, please indicate so on the 1999 dues form where the question is posed. If you do not respond in the affirmative either on the dues form or by direct notification of the Secretary-Treasurer's office, you will not be listed in the internet directory.

Dues

Dues notices for 1999 were sent in August. Members who have not paid their dues by December 31, 1998, will not be eligible for abstract acceptance, listing in the Directory, or Journal and Association mailings.


NEUROPATHOLOGY NEWSLETTER
VOL. 9, NUMBER 3
October 1998


American Association of Neuropathologists, Inc.
Office of the Secretary-Treasurer
Department of Lab Medicine & Pathology
University of Minnesota Medical School
Box 174 Mayo, 420 Delaware St. S.E.
Minneapolis, MN 55455

Email: info@aanp-jnen.com.
www.aanp-jnen.com

Officers
Jeannette J. Townsend, President
Floyd H. Gilles, Vice-President
Suzanne S. Mirra, President-elect
Dawna L. Armstrong, Vice-President-elect
Clayton A. Wiley, Vice-President for Professional Affairs
H. Brent Clark, Secretary-Treasurer
Joseph E. Parisi, Assistant Secretary-Treasurer

Other Executive Council Members
Mauro Dal Canto

Stephen J. De Armond
Pierluigi Gambetti
Bernardino Ghetti
Michael N. Hart
John Q. Trojanowski
E. Tessa Hedley-Whyte

Committee Chairs
Awards — Barbara J. Crain
Constitution — Christine Hulette
International Congresses — Bernardino Ghetti
Membership — Jonathan D. Fratkin
Professional Affairs — Clayton A. Wiley
Program — Bradley T. Hyman

International Society of Neuropathology

Councilors
Orso Bugiani
Peter C. Burger
David N. Louis
George Perry
Cedric S. Raine

Newsletter Editor
H. Brent Clark