American Association of Neuropathologists
Volume 9, Number 1     March, 1998

World Wide Web Site
Professional Affairs Update
1998 Membership Directory
1998 Meeting
    Special Course
    Presidential Symposium
Future Meetings
Newsletter and Society Information

World Wide Web Site
The American Association of Neuropathologists and The Journal of Neuropathology and Experimental Neurology have a new World Wide Web site. Our address:


Professional Affairs Committee
Life in academic neuropathology is beginning to feel an awful lot like a roller coaster ride. With all academic health centers feeling the pinch of managed care, some pathology departments have been depleted to near oblivion. To add insult to injury, the Federal Government continues its witch hunt, retroactively and selectively auditing Medicare billing practices by U.S. teaching physicians. Bringing to bear full Federal legal powers, audits of such vast scope lead even the truly innocent to seriously consider pleading "nolo contendere" in order to avoid lengthy (and expensive) legal battles. Perhaps the Justice Department plans on using its windfall settlements to improve America's health care? If so, they may have to save their winnings to fight the countersuit filed by over two dozen medical associations noting the absurdity of retroactively applying billing rules to bills submitted years earlier. What a mess!

Just when things began to appear to be in a never ending downward spiral, our President makes his State of the Union Address proposing a whopping $1.15 billion increase in NIH budgets. And if that were not enough, he further proposes a 50% increase over the next 5 years. Don't pinch me, I am enjoying this dream.

Seriously, tears come to my eyes when I think of such an easy political target as biomedical research escaping the budget ax. The cynic would have to wonder why so many dollars are spent on a constituency of investigators with so few votes. What are "we" doing right that has the public, through its elected officials, supporting such a tenuous biomedical enterprise? Hope to alleviate catastrophic disease.

So where does Neuropathology fit in this enterprise? Perhaps it is time to

take stock of our most vital resource, our trainees. How well are they prepared to participate in the continuing investigation toward understanding neurologic disease? At the next AANP Professional Affairs meeting we will extend our previous efforts to document current training efforts and develop a database to monitor our success at positioning our trainees. Those members with suggestions or interest in helping with these important issues are encouraged to contact me or any of the Professional Affairs Committee members.

In addition to a bigger budget, many other changes are occurring at NIH. All institutes have decided to eliminate the R29 proposal category in an acknowledgment that more resources are necessary to allow first time awardees success in later grant submissions. Peer review groups have been entirely restructured as outlined at the following website. The composition of the new study sections is currently under construction, but it is crucial that neuropathologists, particularly those with funded research programs, volunteer their time to participate in this important process.

Finally an institute particularly aligned with Neuropathology, the National Institute of Neurologic Diseases and Stroke (NINDS), has recently undergone a change of directorship. On December 15, 1997, Dr. Zachary Hall returned to UCSF and Dr. Audrey S. Penn was appointed the new director. I am sure that most would agree Dr. Hall did an excellent job as Director, and we greatly appreciate his time and efforts to guiding this institute.

     See you in Minneapolis.

Clayton A. Wiley, M.D., Ph.D.
Vice President for Professional Affairs


The 1998 directory of members will be sent out with your May copy of the "Journal of Neuropathology and Experimental Neurology." According to the Association's policy, members who did not pay 1998 dues are not listed.


Please send your new address, including, phone, fax, and email address directly to the Secretary/ Treasurer's Office. Notification to the Journal alone will not update the Association records or Directory listings.



To register for the Meeting, please fill out the enclosed Registration Form. As in the past, there is no registration fee for members. Meeting registration fees for non-members are $30.00 (student/resident/fellow) and $50.00 (faculty/staff).

If you would like to register to attend the Special Course, please include $125.00* with your meeting registration form. *The Course registration fee for Affiliate members is $100. Non-members who are currently in graduate school, residency, or post-doctoral fellowships are eligible for a reduced Special Course registration fee of $100. Documentation of enrollment in a training program must be provided with payment to receive reduced fee. This reduction in fees for trainees was made possible by a gift from the Ronald and Nancy Reagan Research Institute of the Alzheimers Association.

Please indicate on the Registration Form if you wish to attend the Reception, and include additional payment ($10.00 members/faculty and $5.00 for students/residents/fellows).

Send the completed Registration Form to the Secretary-Treasurer at the address specified on the form. Please make any changes in your address, phone, fax, and email for the files of the Secretary/Treasurer's Office directly on the registration form.


Enclosed are hotel reservation forms, which must be received by the hotel no later than 4 weeks in advance to guarantee rooms at the convention rates. You may mail or fax the form directly to the Hyatt Regency Hotel. After May 16, 1998 rooms will be confirmed on an availability basis.

SPECIAL COURSE (Thursday June 18, 8 AM)

This year's course, "Advances in the Postmortem Diagnosis of Common and Uncommon Neurodegenerative Diseases of the Elderly" has been organized by President Dr. John Q. Trojanowski and Dr. Dennis Dickson.

Course Objective: One of the central objectives of research on human neurodegenerative diseases of the elderly is to develop therapies that might prevent or slow the progression of these diseases. While targets for such therapies will emerge from mechanistic insights into these diseases, a prerequisite for all efforts to test novel therapies is the separation of these diseases into different clinically and pathologically relevant or distinct diagnostic categories. For example, recent advances in Alzheimer's disease (AD) research have emphasized the heterogeneous genetic causes of AD, while at the same time underlining some of the commonalties among the hallmark pathologies of AD. Similarly, dementias that are AD-like from a clinical perspective may be due to different underlying pathologies and mechanisms. Thus, it is important to separate these AD-like dementias from authentic AD. Since postmortem studies often are required for such distinctions to be made, this course will focus on recent advances in the differential diagnosis of neurodegenerative diseases of the elderly, many of which may be confused with AD during life. The speakers in the course will seek to incorporate the latest insights into the respective conditions that they discuss in order to define the most current methods for postmortem diagnosis. Where feasible, they will then emphasize how such concepts can be extrapolated to the antemortem diagnosis of the same conditions in order to facilitate the conduct of meaningful clinical trials.

The American Association of Neuropathologists is accredited by the Accreditation Council for Continuing Medical Education to sponsor continuing medical education for physicians.

The American Association of Neuropathologists designates the Special Course as a continuing medical education activity for 6 credit hours in Category I of the Physician's Recognition Award of the American Medical Association.

Special Course AGENDA

Course Organizers: John Q. Trojanowski and Dennis Dickson


John Q. Trojanowski
"Introduction to the Course"
Dr. Suzanne Mirra
Department of Pathology
Emory University, Atlanta, GA

"Update on the Diagnosis of Alzheimer's Disease"
Dr. Kurt Jellinger
University of Vienna
"Differential Diagnosis of Parkinson's Disease With and Without Dementia"
Refreshment Break

Dr. Larry A. Hansen
Department of Neuroscience
University of California San Diego

"Differential Diagnosis of Lewy Body other than Parkinson's Disease"
Dr. Dennis Dickson
Department of Pathology
Albert Einstein School of Medicine

"Differential Diagnosis of Cortical Basal Degeneration and Progressive Supranuclear Palsy"
Lunch Break

Dr. Kiyomitsu Oyanagi
Department of Neuropathology
Tokyo Metropolitan Institute for Neuroscience

"Diagnosis of Guam ALS/PDC and its Relationship to Parkinson's Disease, Alzheimer's Disease, and Amyotrophic Lateral Sclerosis Elsewhere in the World"
Dr. Catherine Bergeron
Department of Neuropathology
Toronto Western Hospital

"Differential Diagnosis of Pick's Disease and Contrast with Dementia Lacking Distinctive Histopathology"
Refreshment Break

Dr. Peter Lantos
Department of Neuropathology


Question and Answer Period


This year approximately 240 abstracts have been accepted for platform and poster sessions. Scientific sessions will be held on Friday and Saturday and will include both poster and platform presentations. Two platform sessions will be conducted concurrently and there will be two poster sessions (morning and afternoon) on each day.

The poster surfaces available to us measure 4 feet by 8 feet. Please prepare your poster accordingly. Bring your own push-pins (preferably 5/8" long) to the meeting. Thumb tacks will not be adequate to fasten your display to the poster boards. Members are responsible for disseminating this information to their residents, fellows and guests. There will be two poster discussion sessions each day.

NOTICE FOR AUTHORS OF ABSTRACTS: "Authors of abstracts that have been published as full length papers are reminded that they are responsible for informing the Secretary-Treasurer's office of this prior to the meeting. Abstracts of previously published papers are not eligible for the Association Awards."

RECEPTION (Friday evening, June 19, 6:30 PM

A reception for the attendees and guests will be held at the Hyatt Regency Hotel on Friday evening. There will be hors d'oeuvres and a cash bar. Admission is $10.00 and $5.00 for students/residents/fellows. Those who wish to attend may submit payment with the pre-registration form, or may purchase tickets at the time of the meeting.

SAUL R. KOREY LECTURE (Saturday, June 20, 11 AM)

The lecture named in honor of Dr. Saul R. Korey will be given by Dr. Sandra H. Bigner, entitled, "Molecular Genetics of Medulloblastoma".

DIAGNOSTIC SLIDE SESSION (Saturday, 8:00 PM, June 20)

Slides and protocols may be purchased for $40 in U.S. currency. Foreign checks, including Canadian, must be issued through an American Bank with a proper routing number. Mail checks to:

Leroy R. Sharer, M.D.
Department of Pathology
New Jersey Medical School
185 South Orange Avenue
Newark, NJ 07103

Slide sets are limited to one per person. Make checks payable to "Diagnostic Slide Session." The protocols will be sent from New Jersey, and the slides from Boston, on or about May 1. Slide delivery before the meeting on any orders received after May 16, 1998 cannot be guaranteed.


Presidential Address:

John Q. Trojanowski, M.D., Ph.D.
Department of Laboratory Medicine and Pathology
University of Pennsylvania

"Diagnostic and Therapeutic Implication of Neuronal Cytoskeletal Abnormalities in Alzheimer's Disease and Lewy Body Disorders."

Matthew T. Moore Distinguished Lecturer:

James Eberwine, Ph.D.
Department of Laboratory Medicine and Pathology
University of Pennsylvania

"Single Cell Molecular Implication of Neuronal Cytoskeletal Neuropathology."
Virginia M.-Y. Lee, Ph.D.
Department of Laboratory Medicine and Pathology
University of Pennsylvania

"Metabolism and Processing of Aß in Implication of Neuronal Cytoskeletal Neurons: Implications for the Pathogenesis of Alzheimer's Disease."
S.E. Arnold, M.D.
Department of Laboratory Medicine and Pathology
University of Pennsylvania

"Dementia in Schizophrenia: Implication of Neuronal Cytoskeletal Neurodevelopmental or Neurodegenerative Disorder?"

Future Meetings

1999: The Portland Hilton Hotel, Portland, Oregon, June 17–20.

2000: Radisson Hotel, Atlanta, GA, June 8–11.

MARCH 1998

American Association of Neuropathologists, Inc.
Office of the Secretary-Treasurer
Department of Lab Medicine & Pathology
University of Minnesota Medical School


John Q. Trojanowski, President
Margaret Z. Jones, Vice-President
Jeannette J. Townsend, President-elect
Floyd H. Gilles, Vice-President-elect
Clayton A. Wiley, Vice-President for Professional Affairs
H. Brent Clark, Secretary-Treasurer
Joseph E. Parisi, Assistant Secretary-Treasurer

Other Executive Council Members
Linda C. Cork

Stephen J. De Armond
Pierluigi Gambetti
Bernardino Ghetti
Michael N. Hart
E. Tessa Hedley-Whyte
James M. Powers

Committee Chairs
Awards — Raymond Sobel
Constitution — Margaret Z. Jones
International Congresses — Bernardino Ghetti
Membership — David E. Wolfe
Professional Affairs — Clayton A. Wiley
Program — Bradley T. Hyman

International Society of Neuropathology

Peter C. Burger
Bernardino Ghetti
Reid R. Heffner, Jr.
George Perry
Cedric S. Raine

Newsletter Editor
H. Brent Clark